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Rafick-Pierre Sékaly, Ph.D.
Rafick-Pierre Sékaly, Ph.D., is a professor at Université de
Montréal. Dr. Sékaly obtained his Ph.D. in Biochemistry in
1984 and completed a postdoctoral fellowship, which was on immunogenetics
and molecular biology of major histocompatibility complex molecules, in
1987 at the Université of Lausanne. His research is focused on using
novel technologies and a multidisciplinary approach to develop therapies
for the prevention and treatment of chronic diseases like AIDS, hepatitis
C and cancer. He has made seminal discoveries involving the characterization
of interactions between the envelope protein of HIV gp120, class II MHC
molecules, and the T cell determinant, CD4. As Scientific Director of the
National Immune Monitoring Laboratory, Sekaly’s group was among the
first to demonstrate that the thymus, the major site of T cell production,
was still active in adults and was the target of viruses such as HIV. In
addition, Sékaly and his team developed several assays that allow
the characterization of the qualitative and quantitative features of the
immune response using multiparametric flow cytometry at the single cell
level, including class I and class II tetramers.
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